Cryo-EM structure of human mitochondrial trifunctional protein
نویسندگان
چکیده
منابع مشابه
[Mitochondrial trifunctional protein deficiency].
We examined the enzyme protein and biosynthesis of human trifunctional protein harboring enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase activity in cultured skin fibroblasts from two patients with longchain 3-hydroxyacyl-CoA dehydrogenase deficiency. The following results were obtained. (a) In cells from patient 1, immunoblot analysis and pulse-chase experimen...
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Secondary structure of protein, such as α-helix and βsheet, is the general three-dimensional (3D) form of local segments. It can be identified from the 3D electron cryomicroscopy (cryo-EM) density images at medium resolutions (~5-10Å). A detected β-sheet can be represented by either the voxels of β-sheet density or by many piecewise polygons to compose a rough surface. However, none of these is...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1801252115